Traceless polymer-supported divergent synthesis of quinoxalinones by microwave irradiation

Chien Hung Shen, Chih Chung Tseng, Cheng Hsun Tasi, Suhas A. Shintre, Li Hsun Chen, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A novel protocol for rapid assemble of quinoxalinones framework has been demonstrated. This method incorporated with soluble polymer support provides a convenient approach for diversification of heterocyclic compounds and for easy purification via facile precipitation from reaction matrix. The key transformation of this study involves in situ reduction of aromatic nitro compound, tandem lactamization concomitant with traceless cleavage of the polymer support under microwave irradiation in a one-pot fashion. Moreover, forward synthetic routes were introduced to maximize complexity of the master intermediate on which further chemical elaboration was applied. The strategy is envisaged to apply for establishment of drug-like small-molecule libraries for high-throughput screening.

Original languageEnglish
Pages (from-to)3532-3540
Number of pages9
JournalTetrahedron
Volume68
Issue number18
DOIs
StatePublished - 6 May 2012

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