Traceless liquid phase synthesis of piperazinediones

Chung-Ming Sun*, K. M.K. Swamy, Mei Jung Lin, Wen Ben Yeh, Fred Y. Chen, Wei Hong Tseng

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Liquid phase combinatorial synthesis (LPCS) of piperazinediones by the use of soluble polymer support is explored to generate libraries. Proline anchored polyethylene glycol monomethyl ether (PEG) underwent dipeptide formation with different Fmoc-amino acids in the presence of dicyclohexyl carbodiimide (DCC). Deprotection of Fmoc accompanied with the cleavage from polymer support with cyclization of dipeptide to piperazinediones offers a facile and effective way to prepare diverse combinatorial libraries. Excellent yields and purities were achieved by simple wash and precipitation method.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalCombinatorial Chemistry and High Throughput Screening
Volume6
Issue number2
DOIs
StatePublished - 1 Jan 2003

Keywords

  • Liquid phase combinatorial synthesis (LPCS)
  • Piperazinedione

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