Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties

Yao Hsuan Lai, Soumik Mondal, Hsin Tzu Su, Sheng Cih Huang, Mine Hsine Wu, I. Huang, Tsai Ling Yang Lauderdale, Jen Shin Song, Kak Shan Shia, Kwok-Kong Mong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. The synthesis features an acetate-assisted arylation method for construction of the hindered B-ring in the core component and a one-pot aromatization-deiodination-denbenzylation procedure to streamline the global functional and protecting group manuipulation. Subsequent cytotoxicity and antibacterial studies revealed that the landomycin R is a potential antibacterial agent against methicillin-resistantStaphylococcus aureus.

Original languageEnglish
Pages (from-to)9426-9432
Number of pages7
JournalRSC Advances
Volume11
Issue number16
DOIs
StatePublished - 23 Feb 2021

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