Time-resolved mass spectrometry

Yu-Chie Chen, Pawel L. Urban*

*Corresponding author for this work

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Mass spectrometry (MS) offers advantages over conventional spectroscopic assays because it enables structural determination of reactants while preserving temporal resolution. The ability to detect short-lived reaction intermediates or labile metabolites makes time-resolved MS (TRMS) measurements an enabling tool for studies of chemical reactions, chemical kinetics and bio-chemical dynamics. High temporal resolution requires careful optimization of the interface, which would enable quenching of the chemical process, ionization and rapid transfer of the analytes into the mass analyzer.We review recent advances in TRMS, and outline the prospects for future developments and applications.

Original languageEnglish
Pages (from-to)106-120
Number of pages15
JournalTrAC - Trends in Analytical Chemistry
Volume44
DOIs
StatePublished - 1 Jan 2013

Keywords

  • Biochemical dynamics
  • Chemical reaction
  • Fast process
  • Kinetic measurement
  • Mass spectrometry
  • Reaction intermediate
  • Reaction monitoring
  • Structural determination
  • Temporal resolution
  • Time-resolved mass spectrometry

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