Thickness dependence of optical second harmonic generation in collagen fibrils

Shi Wei Chu*, Shih Peng Tai, Ming Che Chan, Chi Kuang Sun, I. Ching Hsiao, Chi Hung Lin, Yung Chih Chen, Bai G. Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Simultaneous backward and forward second harmonic generations from isolated type-I collagen matrix are observed. Optical interference behaviors of these nonlinear optical signals are studied with accurately determined fibril thickness by an atomic force microscope. The nonlinear emission directions are strongly dependent on the coherent interaction within and between collagen fibrils. A linear relationship is obtained to estimate collagen fibril thickness with nanometer precision noninvasively by evaluating the forward/backward second harmonic generation ratio.

Original languageEnglish
Pages (from-to)12005-12010
Number of pages6
JournalOptics Express
Issue number19
StatePublished - 17 Sep 2007

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