We theoretically propose laser manipulation utilizing the resonant nonlinear optical response. We calculated the radiation force exerted on a single molecule in a focused laser beam by solving density matrix equations using the non-perturbative method, because the high laser power is necessary for single molecular trapping. As the result, we coherently elucidate certain recently reported puzzling phenomena that contradict the conventional understanding of laser manipulation. Further, we demonstrate unconventional forms of laser manipulation which drastically enhances the number of degrees of freedom to manipulate nano-sized objects. For example, we can "pull"objects by using traveling wave that usually "pushes"them along the direction of traveling wave.