The imaging behavior of an MRI contrast agent [Gd(TTDA-BOM)] 2- in a mice liver tumor model at 3 tesla

Jo Chi Jao, Hsiang Chin Lu, Hsin Ying Lu, Yun-Ming Wang, Gin Chung Liu, Li Min Lin, Pei Yu Chu, Shih Hsie Chen, Po Chou Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

[Gd(TTDA-BOM)] 2- is a newly developed paramagnetic contrast agent. The aim of this study was to investigate the magnetic resonance imaging (MRI) behavior of [Gd(TTDA-BOM)] 2- in mice with implanted AS-30D (Chang hepatoma ascites, CHA) tumor in liver at a 3T high-field whole-body magnetic resonance (MR) scanner. The high-field MR scanner is expected to have a higher signal-to-noise ratio (SNR). The dynamic MRI studies show that the signal enhancement in liver is larger than that in tumor, so that the contrast-to-noise ratio (CNR) between liver and tumor increases after [Gd(TTDA-BOM)] 2- injection. During one-hour investigation, it was found that [Gd(TTDA-BOM)] 2- could stay in liver up to one hour. On the contrary, [Gd(DTPA)] 2- , a kind of commercial contrast agent, was excreted from liver quickly. Therefore, the CNR between liver and tumor using [Gd(TTDA-BOM)] 2- is larger than that using [Gd(DTPA)] 2- and remains high at least up to one hour. In conclusion, [Gd(TTDA-BOM)] 2- might have good potential for being a hepatobiliary MR contrast agent.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalJournal of Medical and Biological Engineering
Volume30
Issue number3
StatePublished - 16 Sep 2010

Keywords

  • 3T
  • Gd(TTDA-BOM)
  • Liver
  • Magnetic resonance imaging (MRI)
  • Paramagnetic contrast agent
  • Tumor

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    Jao, J. C., Lu, H. C., Lu, H. Y., Wang, Y-M., Liu, G. C., Lin, L. M., Chu, P. Y., Chen, S. H., & Chen, P. C. (2010). The imaging behavior of an MRI contrast agent [Gd(TTDA-BOM)] 2- in a mice liver tumor model at 3 tesla. Journal of Medical and Biological Engineering, 30(3), 139-144.