Abstract
We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.
Original language | English |
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Pages (from-to) | 54-61 |
Number of pages | 8 |
Journal | Toxicology and Applied Pharmacology |
Volume | 219 |
Issue number | 1 |
DOIs | |
State | Published - 15 Feb 2007 |
Keywords
- Centaurein
- Flavonoid
- IFN-γ
- Listeria