The effect of centaurein on interferon-γ expression and Listeria infection in mice

Shu Lin Chang; Hsu Hua Yeh; Yu Shiun Lin; Yi Ming Chiang; Tung-Kung Wu; Wen Chin Yang

doi:10.1016/j.taap.2006.11.026

The effect of centaurein on interferon-γ expression and Listeria infection in mice

Shu Lin Chang, Hsu Hua Yeh, Yu Shiun Lin, Yi Ming Chiang, Tung-Kung Wu^*, Wen Chin Yang

^*Corresponding author for this work

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.

Original language	English
Pages (from-to)	54-61
Number of pages	8
Journal	Toxicology and Applied Pharmacology
Volume	219
Issue number	1
DOIs	https://doi.org/10.1016/j.taap.2006.11.026
State	Published - 15 Feb 2007

Keywords

Centaurein
Flavonoid
IFN-γ
Listeria

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title = "The effect of centaurein on interferon-γ expression and Listeria infection in mice",

abstract = "We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.",

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AU - Wu, Tung-Kung

AU - Yang, Wen Chin

PY - 2007/2/15

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AB - We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.

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The effect of centaurein on interferon-γ expression and Listeria infection in mice

Abstract

Keywords

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