Abstract
We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.
| Original language | English |
|---|---|
| Pages (from-to) | 54-61 |
| Number of pages | 8 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 219 |
| Issue number | 1 |
| DOIs | |
| State | Published - 15 Feb 2007 |
Keywords
- Centaurein
- Flavonoid
- IFN-γ
- Listeria
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Chang, S. L., Yeh, H. H., Lin, Y. S., Chiang, Y. M., Wu, T-K., & Yang, W. C. (2007). The effect of centaurein on interferon-γ expression and Listeria infection in mice. Toxicology and Applied Pharmacology, 219(1), 54-61. https://doi.org/10.1016/j.taap.2006.11.026