The effect of centaurein on interferon-γ expression and Listeria infection in mice

Shu Lin Chang, Hsu Hua Yeh, Yu Shiun Lin, Yi Ming Chiang, Tung-Kung Wu*, Wen Chin Yang

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalToxicology and Applied Pharmacology
Volume219
Issue number1
DOIs
StatePublished - 15 Feb 2007

Keywords

  • Centaurein
  • Flavonoid
  • IFN-γ
  • Listeria

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