The distribution and drug susceptibilities of clinical Candida species in TSARY 2014

Zi-Li Zhou, Chao Chih Lin, Wen-Li Chu, Yun-Liang Yang, Hsiu Jung Lo

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The species distribution and drug susceptibilities of 1106 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) in 2014 were determined. Candida albicans is still the dominant species, accounting for 35.9%, followed by 28.3% C. glabrata, 26.6% C. tropicalis, 5.2% C. parapsilosis, 1.0% C. krusei, and 3.0% of 13 other species. Interestingly, the prevalence of candidemia caused by C. glabrata in the present study is significantly higher than that in previous three surveys (39/220 vs. 54/471, P = 0.025). We found that 31 (2.8%), 24 (2.2%), 1 (0.09%), and 0 isolates were resistant to fluconazole, voriconazole, anidulafungin, and amphotericin B, respectively. There is a significant increase in fluconazole (P = 0.00002) and voriconazole (P = 0.00006) resistant rates when compared to the isolates collected in 2010. Importantly, all the 24 voriconazole resistant isolates identified were also resistant to fluconazole. Hence, cross-resistance among azole-type drugs is an emerging issue for managing fungal infections. (C) 2016 Published by Elsevier Inc.
Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume86
Issue number4
DOIs
StatePublished - Dec 2016

Keywords

  • Antifungal; Candida species; Drug susceptibility
  • POPULATION-BASED SURVEILLANCE; INVASIVE FUNGAL-INFECTIONS; BLOOD-STREAM INFECTIONS; IN-VITRO SUSCEPTIBILITY; ANTIFUNGAL SUSCEPTIBILITY; AMPHOTERICIN-B; RISK-FACTORS; PARAPSILOSIS FUNGEMIA; EPIDEMIOLOGY; FLUCONAZOLE

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