The distinct pairing sequence of liver cell and fibroblast on cell-cell fusion platform

Shih Mo Yang, Chun Yen Lin, Shilpa Sivashankar, Srinivasu Valagerahally Puttaswamy, Yen Ta Lu, Hwan You Chang, Long Hsu, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Recently we are developing the cell-cell fusion platform which has a potential to modify cell behavior for degenerative diseases. We present a cell-cell pairing platform to trap and pair mobile HepG2 liver cells and 3T3 fibroblast cells. A 10μm×20μm metal electrode is placed precisely inside a lateral cavity. The lateral cavity design bends the electric field and enlarges the positive dielectrophoresis force. Besides, the structure provides a shelter function to diminish the damage of direct flow shear stress acting on trapped cells. Finally, we demonstrate the distinct liver and fibroblast cells pairing sequence for the future application of cell-cell fusion.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages849-851
Number of pages3
StatePublished - 1 Dec 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2 Oct 20116 Oct 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume2

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period2/10/116/10/11

Keywords

  • Cell pairing
  • Cell trapping
  • Dielectrophoresis
  • Liver cell

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