The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG2[Gd(TTDA-BOM)]

Jo Chi Jao*, Yun-Ming Wang, Ming Hung Ou, Shih Hsie Chen, Yen Ku Chen, Twei Shiun Jaw, Gin Chung Liu, Po Chou Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

[Gd(TTDA-BOM)]2- is a newly developed paramagnetic contrast agent. The ligand, TTDA-BOM, bears a benzyloxymethyl group so that the lipophilicity is increased. The water exchange rate for [Gd(TTDA-BOM)] 2- is significantly higher than that of [Gd(DTPA)]2- and [Gd(BOPTA)]2-. In addition, the bound relaxivity of this Gd (III) complex has a remarkably high value with HSA. Therefore, it has potential to be used as a blood pool contrast agent for MRI. The aim of this study is to investigate the characterization and imaging behavior of NMG 2[Gd(TTDA-BOM)] in normal rat livers and hearts using a 3T high field whole-body MR scanner. The high field MR scanner is expected to have a higher signal to noise ratio. The relaxivities r1 and r2 for [Gd(TTDA-BOM)]2- at 3T are 5.97 mM-1 s-1 and 7.99 mM-1 s-1 respectively, which are higher than those for [Gd(DTPA)]2 (r1=4.64 mM-1 s-1 and r2=5.08 mM-1 s-1). The dynamic MRI studies show that there is marked enhancement in livers and hearts right after the bolus injection and the enhancement ratios keep high until two hours. In conclusion, [Gd(TTDA-BOM)]2- might have a good potential in both cardiovascular and hepatobiliary applications.

Original languageEnglish
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages1650-1651
Number of pages2
DOIs
StatePublished - 1 Dec 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: 1 Sep 20054 Sep 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Conference

Conference2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period1/09/054/09/05

Keywords

  • 3T
  • Gd(DTPA)
  • Gd(TTDA-BOM)
  • Magnetic resonance imaging
  • Paramagnetic contrast agent

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