Template-based scoring functions for visualizing biological insights of H-2Kb-peptide-TCR complexes

I. Hsin Liu*, Yu Shu Lo, Jinn-Moon Yang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Class-I major histocompatibility complex (MHC), peptide, and T-cell receptor (TCR) play an essential role of adaptive immune responses. Many prediction servers are available for identification of peptides that bind to MHC class I molecules. These servers are often lack of detailed interacting residues and binding models for analyzing MHC-peptide-TCR interaction mechanisms. This study numerously enhanced the template-based scoring function derived from protein-protein interactions for identifying MHC-peptide-TCR binding models. The scoring function considers both the template similarity and interacting force to ensure the statistically significant interface similarity between the peptide candidates and structure templates. The result shows that our scoring function is comparative to the public websites for identifying MHC binding peptides. Our model, considering both the MHC-peptide and peptide-TCR interfaces, is able to provide visualization and the biological insights of MHC-peptide-TCR binding models. We believe that our model is useful for the development of peptide-based vaccines.

Original languageEnglish
Title of host publicationProceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
Pages127-132
Number of pages6
DOIs
StatePublished - 1 Dec 2010
Event2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010 - Hong Kong, China
Duration: 18 Dec 201021 Dec 2010

Publication series

NameProceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010

Conference

Conference2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
CountryChina
CityHong Kong
Period18/12/1021/12/10

Keywords

  • Component
  • H-2k
  • MHC-peptide-TCR complex
  • Protein-peptide interaction
  • Template-based scoring function

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