Temperature-sensitive nanocapsules for controlled drug release caused by magnetically triggered structural disruption

Ting Yu Liu*, Kun Ho Liu, Dean-Mo Liu, San-Yuan Chen, I. Wei Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

Self-assembled nanocapsules containing a hydrophilic core and a crosslinked yet thermosensitive shell are successfully prepared using poly(ethyleneoxide)- poly(propylene-oxide)-poly(ethylene-oxide) block copolymers, 4-nitrophenyl chloroformate, gelatin, and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The core is further rendered magnetic by incorporating iron oxide nanoparticles via internal precipitation to enable externally controlled actuation under magnetic induction. The spherical nanocapsules exhibit a hydrophilk-to-hydrophobic transition at a characteristic but tunable temperature reaching 40 °C, triggering a size contraction and shrinkage of the core. The core content experiences very little leakage at 25 °C, has a half life about 5 h at 45 °C, but bursts out within a few minutes under magnetic heating due to iron oxide coarsening and core/shell disruption. Such burst-like response may be utilized for controlled drug release as illustrated here using a model drug Vitamin B12.

Original languageEnglish
Pages (from-to)616-623
Number of pages8
JournalAdvanced Functional Materials
Volume19
Issue number4
DOIs
StatePublished - 24 Feb 2009

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