Abstract
Making use of temperature-controlled thiation as a key operation, a simple route to 2-aminothiophenes or thieno[2,3-c]isothiazoles has been newly developed wherein the 2-aminothiophene nucleus was formed through an initial formation of thioamide followed by a 5-exo-dig addition to the tethered alkyne; however, under harsher thermal conditions, excess sulfur-transferring reagents enabled further oxidative thiation to generate the corresponding thieno[2,3-c]isothiazoles.
Original language | English |
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Pages (from-to) | 14688-14697 |
Number of pages | 10 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 23 |
DOIs | |
State | Published - 7 Dec 2018 |