Targeting cancer stem cells: Emerging role of Nanog transcription factor

Mong Lien Wang, Shih Hwa Chiou, Cheng-Wen Wu Lee*

*Corresponding author for this work

Research output: Contribution to journalReview article

107 Scopus citations

Abstract

The involvement of stemness factors in cancer initiation and progression has drawn much attention recently, especially after the finding that introducing four stemness factors in somatic cells is able to reprogram the cells back to an embryonic stem cell-like state. Following accumulating data revealing abnormal elevated expression levels of key stemness factors, like Nanog, Oct4, and Sox2, in several types of cancer stem cells; the importance and therapeutic potential of targeting these stemness regulators in cancers has turned to research focus. Nanog determines cell fate in both embryonic and cancer stem cells; activating Nanog at an inappropriate time would result in cancer stem cells rather than normal pluripotent stem cells or differentiated somatic cells. Upregulated Nanog is correlated with poor survival outcome of patients with various types of cancer. The discoveries of downstream regulatory pathways directly or indirectly mediated by Nanog indicate that Nanog regulates several aspects of cancer development such as tumor cell proliferation, self-renewal, motility, epithelial-mesenchymal transition, immune evasion, and drug-resistance, which are all defined features for cancer stem cells. The current review paper illustrates the central role of Nanog in the regulatory networks of cancer malignant development and stemness acquirement, as well as in the communication between cancer cells and the surrounding stroma. Though a more defined model is needed to test the therapeutic efficacy of targeting Nanog as a cancer treatment method, current animal experiments using siNanog or shNanog have shown the promising therapeutic potential of Nanog targeting in several types of cancer.

Original languageEnglish
Pages (from-to)1207-1220
Number of pages14
JournalOncoTargets and Therapy
Volume6
DOIs
StatePublished - 19 Sep 2013

Keywords

  • Cancer stemness
  • Target therapy

Fingerprint Dive into the research topics of 'Targeting cancer stem cells: Emerging role of Nanog transcription factor'. Together they form a unique fingerprint.

  • Cite this