Synthesis, thermodynamics and relaxivity studies for the complexation of Gd3+, Ca2+, Cu2+ and Zn2+ by N,N″-bis(amide) derivatives of diethylenetriaminepentaacetic acid

Yun-Ming Wang*, Su Tin Lin, Yueh Ju Wang, Reu Sheng Sheu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Three bis(amide) derivatives of H5dtpa [(carboxymethyl)iminobis(ethylenenitrilo)tetraacetic acid], H3L1 = bis(adamantanamide), H3L2 = bis(2-methoxybenzylamide), and H3L3 = bis(2-methoxyphenethylamide) were synthesized. Their protonation constants were determined by potentiometric titration in 0.10 mol dm-3 KCl and by NMR pH titration at 25.0±0.1°C. Stability and selectivity constants are measured to evaluate the possibility of using the corresponding gadolinium (III) complexes for magnetic resonance imaging contrast agents. Low stability or selectivity constants indicate higher possibility for releasing free Gd3+ ion and free ligand as well from gadolinium(III) complexes. The formations of gadolinium(III), copper(II), zinc(II), and calcium(II) complexes were investigated quantitatively by the potentiometry. The stability constant for gadolinium(III) complex is larger than those for Ca(II), Zn(II), and Cu(II) complexes for these three octadentate ligands. The selectivity constants and modified selectivity constants of the amides for Gd3+ over endogenously available metal ions were calculated. Effectiveness of all three ligands in binding divalent and trivalent metal ions in biological media is assessed by comparing pM values at physiological pH 7.4. Spin-lattice relaxivity R1 for Gd(III) complexes was also determined. The observed relaxivity were found to decrease with increasing pH in the acid range below pH 3 and relaxivity values were become invariant with respect to pH changes over the range of 3-10.

Original languageEnglish
Pages (from-to)2021-2028
Number of pages8
JournalPolyhedron
Volume17
Issue number11-12
DOIs
StatePublished - 1 Jan 1998

Keywords

  • Contrast agents
  • Gadolinium complexes
  • MRI
  • Paramagnetic complexes
  • Relaxivity
  • Thermodynamics

Fingerprint Dive into the research topics of 'Synthesis, thermodynamics and relaxivity studies for the complexation of Gd<sup>3+</sup>, Ca<sup>2+</sup>, Cu<sup>2+</sup> and Zn<sup>2+</sup> by N,N″-bis(amide) derivatives of diethylenetriaminepentaacetic acid'. Together they form a unique fingerprint.

Cite this