Synthesis of Calix[4]arenes with four different 'lower rim' substituents

Chun Mei Shu, Wen-Sheng Chung*, Sing Ho Wu, Zong Chia Ho, Lee Gin Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Calix[4]arenes with four different 'lower rim' substituents were synthesized following six-step sequences. The first alkyl group (R1) was introduced using R1X and CH3ONa, and then reaction with R2X and K2CO3 led to the introduction of a second alkyl group (R2) at the 3-position. Benzoate was introduced as a protecting group at the 1,3-O-disubstituent stage and was removed under basic conditions after the incorporation of the third alkyl group (R3) with R3X and NaH. The final alkyl group (R4) was introduced with R4X and NaH to give the chiral title compounds.

Original languageEnglish
Pages (from-to)2673-2679
Number of pages7
JournalJournal of Organic Chemistry
Volume64
Issue number8
DOIs
StatePublished - 16 Apr 1999

Fingerprint Dive into the research topics of 'Synthesis of Calix[4]arenes with four different 'lower rim' substituents'. Together they form a unique fingerprint.

Cite this