Synthesis of alkylated nitriles by [RuHCl(CO)(PPh3) 3]-catalyzed alkylation of acetonitrile using primary alcohols

Takashi Kuwahara, Takahide Fukuyama, Ilhyong Ryu

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Abstract

Alkylation reaction of acetonitrile using primary alcohols is effectively catalyzed by [RuHCl(CO)(PPh3)3] in the presence of K 3PO4 as a base. Both benzylic and non-benzylic alcohols coupled with acetonitrile to give alkylated nitriles in good yields.

Original languageEnglish
Pages (from-to)1163-1165
Number of pages3
JournalChemistry Letters
Volume42
Issue number10
DOIs
StatePublished - 16 Oct 2013

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