Synthesis of acetylenic ketones by a Pd-catalyzed carbonylative three-component coupling reaction in [bmim]PF6

Takahide Fukuyama, Ryo Yamaura, Ilhyong Ryu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A carbonylative three-component coupling reaction of aryl iodides with terminal alkynes catalyzed by PdCl2(PPh3)2 was carried out using an ionic liquid, [bmim]PF6, as the reaction medium, which resulted in good yields of α,β-acetylenic ketones. The low-viscosity ionic liquid, [bmim]NTf2, was not suitable for this reaction, since the background Sonogashira coupling reaction, a competing reaction, also proceeded.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalCanadian Journal of Chemistry
Volume83
Issue number6-7
DOIs
StatePublished - 1 Jun 2005

Keywords

  • Carbonylation
  • Ionic liquid
  • Palladium
  • Three-component coupling
  • α,β-acetylenic ketones

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