Synthesis and complexation of Gd3+, Ca2+, Cu2+ and Zn2+ by 3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid

Yun-Ming Wang*, Chien Hsun Lee, Gin Chung Liu, Reu Sheng Sheu

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

3,6,10-Tri(carboxymethyl)-3,6,10-triazadodecanedioic acid (H5L), was synthesized and its protonation constants were determined by potentiometric titration in 0.10 mol dm-3 Me4NNO3 and by NMR pH titration at 25.0 ± 0.1°C. Stability and selectivity constants have been measured to evaluate the possibility of using the corresponding gadolinium(III) complex as a magnetic resonance imaging contrast agent. The formations of gadolinium(III), copper(II), zinc(II) and calcium(II) complexes were investigated quantitatively by potentiometry. The stability constant for the gadolinium(III) complex is larger than those of CaII, ZnII and CuII for this octadentate ligand. The selectivity constants and modified selectivity constants of the ligand for Gd3+ over endogenously available metal ions were calculated. The spin-lattice relaxivity R1 for the gadolinium(III) complex was also determined. It was found to decrease with increasing pH below 4 and became invariant with respect to pH over the range 4-10. Oxygen-17 NMR shifts showed that the [DyL]2- complex had one inner-sphere water molecule. The water proton spin-lattice relaxation rate for the [GdL]2- complex was also consistent with one inner-sphere co-ordination position.

Original languageEnglish
Pages (from-to)4113-4118
Number of pages6
JournalJournal of the Chemical Society - Dalton Transactions
Issue number24
DOIs
StatePublished - 21 Dec 1998

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