Synthesis and characterization of PEG-PCL-PEG Triblock copolymers as carriers of doxorubicin for the treatment of breast cancer

Nguyen Van Cuong, Ming Fa Hsieh*, Yung Tsung Chen, Ian Liau

*Corresponding author for this work

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Triblock copolymers of monomethoxy poly(ethylene glycol) (mPEG) and ε-caprolactone (CL) were prepared with varying lengths of poly(ε-caprolactone) (PCL) compositions and a fixed length of mPEG segment. The molecular characteristics of triblock copolymers were characterized by 1H NMR, gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). These amphiphilic linear copolymers based on PCL hydrophobic chain and hydrophilic mPEG ending, which can self-assemble into nanoscopic micelles with their hydrophobic cores, encapsulated doxorubicin (DOX) in an aqueous solution. The particle size of prepared micelles was around 40-92 nm. The DOX loading content and DOX loading efficiency were from 3.7-7.4% to 26-49%, respectively. DOX-released profile was pH-dependent and faster at pH 5.4 than pH 7.4. Additionally, the cytotoxicity of DOX-loaded micelles was found to be similar with free DOX in drugresistant cells (MCF-7/adr). The great amounts of DOX and fast uptake accumulated into the MCF-7/adr cells from DOX-loaded micelles suggest a potential application in cancer chemotherapy.

Original languageEnglish
Pages (from-to)3694-3703
Number of pages10
JournalJournal of Applied Polymer Science
Volume117
Issue number6
DOIs
StatePublished - 15 Sep 2010

Keywords

  • Drug delivery systems
  • Micelles
  • Monomethoxy poly(ethylene glycol)
  • Multidrug resistance
  • Nanoparticles
  • Poly(ε-caprolactone)

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