Synthesis and characterization of mesoporous Gd2O3 nanotube and its use as a drug-carrying vehicle

Yen Po Chang, Kun Ho Liu, Chih Shin Chao, San-Yuan Chen*, Dean-Mo LIu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Gd2O3 nanotubes were constructed for the first time by assembling highly crystalline Gd2O3 nanoparticles through the use of combined soft template and sol-gel methods. Amphiphilic block copolymer was used as structure-directing agent and gadolinium isopropoxide as inorganic precursor in non-aqueous solution. The amphiphilic copolymer molecules are known to undergo self-organization above a critical micelle concentration, forming micellular architecture that further provides a structurally ordered active site for the nucleation and growth of Gd monomers. The resulting self-assembly of the Gd2O3 nanocrystals led to the formation of Gd2O3 tubular nanostructure after pyrolytic removal of the template. Transmission electron microscopy analysis indicated a mesoporous channel array along the [110] direction of the nanotubes where the wall of nanotube is well organized by the assembly of a highly crystalline framework of Gd2O3 nanocrystals. This Gd2O 3 nanotube exhibited weak superparamagnetic property and was found to be able to carry and elute a model molecule, i.e. ibuprofen (IBU), in a controllable manner via an external magnetic field. The mechanism of IBU release from the nanotubes with and without the use of magnetic stimulus was proposed.

Original languageEnglish
Pages (from-to)3713-3719
Number of pages7
JournalActa Biomaterialia
Volume6
Issue number9
DOIs
StatePublished - 1 Jan 2010

Keywords

  • Magnetic-sensitive
  • Nanocrystal
  • Nanotube
  • Self assembly

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