Synthesis and biological evaluation of novel angularly fused polycyclic coumarins

Imtyaz A. Khan, Manohar V. Kulkarni*, M. Gopal, M. S. Shahabuddin, Chung-Ming Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.

Original languageEnglish
Pages (from-to)3584-3587
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number15
DOIs
StatePublished - 1 Aug 2005

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