Synthesis and biological evaluation of novel angularly fused polycyclic coumarins

Imtyaz A. Khan; Manohar V. Kulkarni; M. Gopal; M. S. Shahabuddin; Chung-Ming Sun

doi:10.1016/j.bmcl.2005.05.063

Synthesis and biological evaluation of novel angularly fused polycyclic coumarins

Imtyaz A. Khan, Manohar V. Kulkarni^*, M. Gopal, M. S. Shahabuddin, Chung-Ming Sun

^*Corresponding author for this work

National Chiao Tung University

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.

Original language	English
Pages (from-to)	3584-3587
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2005.05.063
State	Published - 1 Aug 2005

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abstract = "In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.",

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AU - Sun, Chung-Ming

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