Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins

Rajesh G. Kalkhambkar, Geeta M. Kulkarni*, Chandrappa M. Kamanavalli, N. Premkumar, S. M.B. Asdaq, Chung-Ming Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1 H NMR, 13 C NMR, 19 F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.

Original languageEnglish
Pages (from-to)2178-2188
Number of pages11
JournalEuropean Journal of Medicinal Chemistry
Volume43
Issue number10
DOIs
StatePublished - 1 Oct 2008

Keywords

  • Analgesic
  • Anti-bacterial
  • Anti-fungal
  • Anti-inflammatory
  • Fluorinated 1-aza coumarin
  • Fluorinated coumarin

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