Susceptibilities to amphotericin B and fluconazole of Candida species in Taiwan Surveillance of Antimicrobial Resistance of Yeasts 2006

Yun-Liang Yang, An-Huei Wang, Chih-Wei Wang, Wei-Ting Cheng, Shu Ying Li, Hsiu-Jung Lo

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Susceptibilities to amphotericin B and fluconazole of 964 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2006 were determined. There were 419 (43.5%) Candida albicans, 246 (25.5%) Candida tropicalis, 211 (21.9%) Candida glabrata, 62 (6.4%) Candida parapsilosis, 14 (1.5%) Candida krusei, and 12 (1.2%) others. Interestingly, 16 of the 17 amphotericin B-resistant isolates were non-albicans Candida species. The resistant rate to amphotericin B has decreased from 2.5% in 2002 to 1.8% in 2006. On the other hand, there were 132 C. tropicalis, 14 C. krusei, 10 C. albicans, and 9 C. glabrata isolates that had MICs to fluconazole >= 64 mu g/mL. The prevalence of isolates with such high MICs was significantly higher than that in 2002 (17.1% versus 1.9%). Our results further indicate that most of the isolates with MICs to fluconazole >= 64 mu g/mL exhibited the "trailing" phenomenon. (C) 2008 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume61
Issue number2
DOIs
StatePublished - Jun 2008

Keywords

  • Candida; susceptibility; resistance

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