Surface-enhanced hyper-Raman spectroscopy using optical trapping of silver nanoparticles for molecular detection in solution

H. Yoshikawa*, T. Adachi, G. Sazaki, T. Matsui, K. Nakajima, Hiroshi Masuhara

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Optical trapping of silver nanoparticles dispersed with rhodamine 6G (R6G) and NaCl in water gives surface-enhanced hyper-Raman scattering (SEHRS) of R6G. In this paper we have measured the SEHRS spectrum in the R6G concentration range between 10 -7 and 10 -11 M. SEHRS intensity and signal-to-noise ratio show clear differences at the lower R6G concentrations than ∼10 -9 M, indicating that the number of R6G in a trapped silver aggregate approaches the single-molecule level. This trapping SEHRS technique is applied for the detection of lysozyme molecules labelled with tetramethylrhodamine dye.

Original languageEnglish
Article numberS08
JournalJournal of Optics A: Pure and Applied Optics
Volume9
Issue number8
DOIs
StatePublished - 1 Aug 2007

Keywords

  • Lysozyme
  • Optical trapping
  • Rhodamine 6G
  • Silver nanoparticles
  • Surface enhanced hyper-Raman scattering

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