Surface characteristics and hemocompatibility of PAN/PVDF blend membranes

Ting Yu Liu, Wen Ching Lin, Li Ying Huang, San-Yuan Chen, Ming Chien Yang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Polyacrylonitrile (PAN) was blended with polyvinylidine fluoride (PVDF) at various ratios and made into membranes. The hemocompatibility of the resulting membranes was evaluated based on human plasma proteins adsorption, platelet adhesion, thrombus formation, and blood coagulation time. The PAN/PVDF blends exhibited partial miscibility according to the inward shifting of their two glass transition temperatures. The microstructures of blend membranes examined using atomic force Microscopy (AFM) indicated that the roughness increased with the PVDF content, and the phase separation was too severe to form a membrane when the PVDF content was more than 30%. The water contact angle of PAN/PVDF blend membranes increased with the PVDF content. By blending with 20 wt% apolar PVDF the adsorption of blood proteins could be reduced, and hence the platelet adhesion and thrombus formation was also reduced. However, when the PVDF content was 30 wt%, severe thrombogenicity was observed due probably to the more porous structure of blend membrane. These results demonstrated that the hemocompatibility would be improved for PAN/PVDF blend membranes with appropriate hydrophilicity and roughness.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalPolymers for Advanced Technologies
Issue number5
StatePublished - 1 May 2005


  • Blends
  • Membranes
  • Miscibility
  • Polyacrylonitrile
  • Polyvinylidine fluoride

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