Surface-Assisted Laser Desorption/Ionization Mass Spectrometry on Titania Nanotube Arrays

Chun Yuan Lo, Jia Yi Lin, Wei Yu Chen, Cheng Tai Chen, Yu-Chie Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Titania nanotube arrays (NTA) generated from anodizing processes are tested as the substrate for surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). The background generated from titania NTA is very low, making the approach suitable for the analysis of small molecules. The upper detectable mass is ∼29 kDa. Homogeneous sample deposition leads to good shot-to-shot reproducibility and suitability for quantitative analysis. Additionally, phosphopeptides can be selectively trapped on the titania NTA substrate, as illustrated by simply depositing a tryptic digest of β-casein followed by titania NTA SALDI MS analysis. The detection limit for small organics and peptides is in low fmol.

Original languageEnglish
Pages (from-to)1014-1020
Number of pages7
JournalJournal of the American Society for Mass Spectrometry
Volume19
Issue number7
DOIs
StatePublished - 1 Jul 2008

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