Surface-Assisted Laser Desorption/Ionization Mass Spectrometry on Titania Nanotube Arrays

Chun Yuan Lo; Jia Yi Lin; Wei Yu Chen; Cheng Tai Chen; Yu-Chie Chen

doi:10.1016/j.jasms.2008.04.025

Surface-Assisted Laser Desorption/Ionization Mass Spectrometry on Titania Nanotube Arrays

Chun Yuan Lo, Jia Yi Lin, Wei Yu Chen, Cheng Tai Chen, Yu-Chie Chen^*

^*Corresponding author for this work

National Chiao Tung University

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Titania nanotube arrays (NTA) generated from anodizing processes are tested as the substrate for surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). The background generated from titania NTA is very low, making the approach suitable for the analysis of small molecules. The upper detectable mass is ∼29 kDa. Homogeneous sample deposition leads to good shot-to-shot reproducibility and suitability for quantitative analysis. Additionally, phosphopeptides can be selectively trapped on the titania NTA substrate, as illustrated by simply depositing a tryptic digest of β-casein followed by titania NTA SALDI MS analysis. The detection limit for small organics and peptides is in low fmol.

Original language	English
Pages (from-to)	1014-1020
Number of pages	7
Journal	Journal of the American Society for Mass Spectrometry
Volume	19
Issue number	7
DOIs	https://doi.org/10.1016/j.jasms.2008.04.025
State	Published - 1 Jul 2008

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title = "Surface-Assisted Laser Desorption/Ionization Mass Spectrometry on Titania Nanotube Arrays",

abstract = "Titania nanotube arrays (NTA) generated from anodizing processes are tested as the substrate for surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). The background generated from titania NTA is very low, making the approach suitable for the analysis of small molecules. The upper detectable mass is ∼29 kDa. Homogeneous sample deposition leads to good shot-to-shot reproducibility and suitability for quantitative analysis. Additionally, phosphopeptides can be selectively trapped on the titania NTA substrate, as illustrated by simply depositing a tryptic digest of β-casein followed by titania NTA SALDI MS analysis. The detection limit for small organics and peptides is in low fmol.",

author = "Lo, {Chun Yuan} and Lin, {Jia Yi} and Chen, {Wei Yu} and Chen, {Cheng Tai} and Yu-Chie Chen",

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AU - Lo, Chun Yuan

AU - Lin, Jia Yi

AU - Chen, Wei Yu

AU - Chen, Cheng Tai

AU - Chen, Yu-Chie

PY - 2008/7/1

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AB - Titania nanotube arrays (NTA) generated from anodizing processes are tested as the substrate for surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). The background generated from titania NTA is very low, making the approach suitable for the analysis of small molecules. The upper detectable mass is ∼29 kDa. Homogeneous sample deposition leads to good shot-to-shot reproducibility and suitability for quantitative analysis. Additionally, phosphopeptides can be selectively trapped on the titania NTA substrate, as illustrated by simply depositing a tryptic digest of β-casein followed by titania NTA SALDI MS analysis. The detection limit for small organics and peptides is in low fmol.

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