Subdiffraction scattered light imaging of gold nanoparticles using structured illumination

Bo Jui Chang, Shiuan-Huei Lin, Li Jun Chou, Su Yu Chiang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A reflective light-scattering (RLS) microscope with structured illumination (SI) provides subdiffraction resolution and improves the image quality of gold nanoparticles in biological systems. The three-dimensional (3D)-structured pattern is rapidly and precisely controlled with a spatial light modulator and scrambled at the conjugate image plane to increase spatial incoherence. The reconstructed SI-RLS image of 100nm gold nanoparticles reveals lateral and axial resolutions of approximately 117 and 428nm. We present a high-resolution image of gold nanoparticles inside a HeLa cell, with improved contrast.

Original languageEnglish
Pages (from-to)4773-4775
Number of pages3
JournalOptics Letters
Volume36
Issue number24
DOIs
StatePublished - 15 Dec 2011

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