Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

Chiao Wen Chen, Ching Chi Wang, Xin Ru Li, Henryk Witek, Kwok Kong Tony Mong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.

Original languageEnglish
Pages (from-to)3135-3141
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume18
Issue number16
DOIs
StatePublished - 28 Apr 2020

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