Study on dynamics of photon migration in human breast based on three-dimensional Monte Carlo modeling

Ching-Cheng Chuang, Chung Ming Chen, Chia Yen Lee, Jui Che Tsai, Chih Wei Lu, Chia-Wei Sun*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The scattering and absorption properties of human breast are very important for cancer diagnosis based on diffuse optical tomography (DOT). In this study, the dynamics of photon migration in three-dimensional human breast model with various source-detector separations is simulated based on a Monte Carlo algorithm. The three-dimensional human breast structure is obtained from in vivo MRI image. The breast model consists of skin, fatty tissue, glandular tissue, sternum and ribcage. The backscattered diffuse photons from each layer in breast are recorded by marking the deepest layer which every photon can reach. The experimental results indicate that the re-emitted photons contain more information from deep tissue regions with the source-detector separations because of the strong dependence to the resolution and sensitivity in DOT imaging. The geometric position of the source-detector separations were optimized in this study. The different sizes of breast tumor were modeled to analysis of optical image characterizations. Finally, the tumor images from different deep information were obtained with temporal profiles.

Original languageEnglish
Title of host publicationBiomedical Applications of Light Scattering IV
DOIs
StatePublished - 7 May 2010
EventBiomedical Applications of Light Scattering IV - San Francisco, CA, United States
Duration: 23 Jan 201025 Jan 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7573
ISSN (Print)1605-7422

Conference

ConferenceBiomedical Applications of Light Scattering IV
CountryUnited States
CitySan Francisco, CA
Period23/01/1025/01/10

Keywords

  • Breast tumor
  • Diffuse optical tomography (DOT)
  • Monte Carlo algorithm

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