Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsing Pang Hsieh*, Jing Ping Liou, Ying Ting Lin, Neeraj Mahindroo, Jang Yang Chang, Yung Ning Yang, Shuenn Shing Chern, Uan Kang Tan, Chun Wei Chang, Tung Wei Chen, Chi Hung Lin, Ying Ying Chang, Chiung Chiu Wang

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number1
DOIs
StatePublished - 6 Jan 2003

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    Hsieh, H. P., Liou, J. P., Lin, Y. T., Mahindroo, N., Chang, J. Y., Yang, Y. N., Chern, S. S., Tan, U. K., Chang, C. W., Chen, T. W., Lin, C. H., Chang, Y. Y., & Wang, C. C. (2003). Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents. Bioorganic and Medicinal Chemistry Letters, 13(1), 101-105. https://doi.org/10.1016/S0960-894X(02)00850-8