Structural model of the amyloid fibril formed by β2- microglobulin #21-31 fragment based on vibrational spectroscopy

Hirotsugu Hiramatsu, Yuji Goto, Hironobu Naiki, Teizo Kitagawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A structural model of amyloid fibril formed by the #21-31 fragment of β2-microglobulin is proposed from microscope IR measurements on specifically 13C-labeled peptide fibrils and Raman spectra of the dispersed fibril solution. The 13C-shifted amide frequency indicated the secondary structure of the labeled residues. The IR spectra have demonstrated that the region between F22 and V27 forms the core part with the extended β-sheet structure. Raman spectra indicated the formation of a dimer with a disulfide bridge between C25 residues.

Original languageEnglish
Pages (from-to)7988-7989
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number22
DOIs
StatePublished - 8 Jun 2005

Fingerprint Dive into the research topics of 'Structural model of the amyloid fibril formed by β<sub>2</sub>- microglobulin #21-31 fragment based on vibrational spectroscopy'. Together they form a unique fingerprint.

Cite this