Stimuli-Responsive controlled Magnetic-Sensitive silica drug release from nanospheres

Shang Hsiu Hu, Ting Yu Liu, Hsin Yang Huang, Dean-Mo LIu*, San-Yuan Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A novel method for control burst releasing of drug via a high frequency magnetic field (HFMF) from magnetic-sensitive silica nanospheres was developed. The nanospheres were synthesized by a combination of emulsion and sol-gel process with the particles controlled at about 80 nm in diameter. Under repeated exposures to the high frequency magnetic stimulus, the drug release behaviors showed reproducible slow-to-burst profiles while consecutively applying the magnetic stimulus at 10-mm switching time and the release profile restored immediately when the stimulus was removed. By taking this non-contact control-burst method, the magnetic silica nanospheres can be designed to treat the cancer therapy and urgent physiological needs.

Original languageEnglish
Pages (from-to)866-870
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
Issue number2
StatePublished - 1 Jan 2009


  • Controlled drug release
  • Magnetic
  • Nanospheres

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