Stepwise Signal Extraction via Marginal Likelihood

Chao Du, Chu-Lan Kao, S. C. Kou

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

This article studies the estimation of a stepwise signal. To determine the number and locations of change-points of the stepwise signal, we formulate a maximum marginal likelihood estimator, which can be computed with a quadratic cost using dynamic programming. We carry out an extensive investigation on the choice of the prior distribution and study the asymptotic properties of the maximum marginal likelihood estimator. We propose to treat each possible set of change-points equally and adopt an empirical Bayes approach to specify the prior distribution of segment parameters. A detailed simulation study is performed to compare the effectiveness of this method with other existing methods. We demonstrate our method on single-molecule enzyme reaction data and on DNA array comparative genomic hybridization (CGH) data. Our study shows that this method is applicable to a wide range of models and offers appealing results in practice. Supplementary materials for this article are available online.

Original languageEnglish
Pages (from-to)314-330
Number of pages17
JournalJournal of the American Statistical Association
Volume111
Issue number513
DOIs
StatePublished - 2 Jan 2016

Keywords

  • Array comparative genomic hybridization
  • Asymptotic consistency
  • Change-points
  • Choice of prior
  • Dynamic programming
  • Single-molecule experiment

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