Stable functionalization of small semiconducting polymer dots via covalent cross-linking and their application for specific cellular imaging

Jiangbo Yu, Changfeng Wu, Xuanjun Zhang, Fangmao Ye, Maria Elena Gallina, Yu Rong, I. Che Wu, Wei Sun, Yang-Hsiang Chan, Daniel T. Chiu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

A facile cross-linking strategy covalently links functional molecules to semiconducting polymer dots (Pdots) while simultaneously providing functional groups for biomolecular conjugation. In addition to greatly enhanced stability, the formed Pdots are small (<10 nm), which can be difficult to achieve with current methods but is highly desirable for most biological applications. These characteristics are significant for improving labeling efficiency and sensitivity in cellular assays that employ Pdots.

Original languageEnglish
Pages (from-to)3498-3504
Number of pages7
JournalAdvanced Materials
Volume24
Issue number26
DOIs
StatePublished - 10 Jul 2012

Keywords

  • cellular imaging
  • cross-linking
  • polymer dots
  • semiconductors
  • stable functionlization

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