Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.
|Number of pages||5|
|Journal||Diagnostic Microbiology and Infectious Disease|
|State||Published - Jun 2013|
- Antifungal; Candida species; Drug susceptibility
- BLOOD-STREAM INFECTIONS; IN-VITRO SUSCEPTIBILITY; AMPHOTERICIN-B; ANTIFUNGAL SUSCEPTIBILITY; BROTH MICRODILUTION; SURVEILLANCE PROGRAM; INVASIVE CANDIDIASIS; TRAILING GROWTH; NORTH-AMERICA; FLUCONAZOLE
Yang, Y-L., Chen, H-T., Lin, C. C., Chu, W-L., & Lo, H-J. (2013). Species distribution and drug susceptibilities of Candida isolates in TSARY 2010. Diagnostic Microbiology and Infectious Disease, 76(2), 182-186. https://doi.org/10.1016/j.diagmicrobio.2013.03.003