Species distribution and drug susceptibilities of Candida isolates in TSARY 2010

Yun-Liang Yang, Hui-Ting Chen, Chao Chih Lin, Wen-Li Chu, Hsiu-Jung Lo

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Abstract

Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume76
Issue number2
DOIs
StatePublished - Jun 2013

Keywords

  • Antifungal; Candida species; Drug susceptibility
  • BLOOD-STREAM INFECTIONS; IN-VITRO SUSCEPTIBILITY; AMPHOTERICIN-B; ANTIFUNGAL SUSCEPTIBILITY; BROTH MICRODILUTION; SURVEILLANCE PROGRAM; INVASIVE CANDIDIASIS; TRAILING GROWTH; NORTH-AMERICA; FLUCONAZOLE

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