Species distribution and drug susceptibilities of Candida isolates in TSARY 2010

Yun-Liang Yang; Hui-Ting Chen; Chao Chih Lin; Wen-Li Chu; Hsiu-Jung Lo

doi:10.1016/j.diagmicrobio.2013.03.003

Species distribution and drug susceptibilities of Candida isolates in TSARY 2010

Yun-Liang Yang, Hui-Ting Chen, Chao Chih Lin, Wen-Li Chu, Hsiu-Jung Lo

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	182-186
Number of pages	5
Journal	Diagnostic Microbiology and Infectious Disease
Volume	76
Issue number	2
DOIs	https://doi.org/10.1016/j.diagmicrobio.2013.03.003
State	Published - Jun 2013

Keywords

Antifungal; Candida species; Drug susceptibility
BLOOD-STREAM INFECTIONS; IN-VITRO SUSCEPTIBILITY; AMPHOTERICIN-B; ANTIFUNGAL SUSCEPTIBILITY; BROTH MICRODILUTION; SURVEILLANCE PROGRAM; INVASIVE CANDIDIASIS; TRAILING GROWTH; NORTH-AMERICA; FLUCONAZOLE

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@article{9e151722e31548c1b7c46a104b5964a4,

title = "Species distribution and drug susceptibilities of Candida isolates in TSARY 2010",

abstract = "Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.",

keywords = "Antifungal; Candida species; Drug susceptibility, BLOOD-STREAM INFECTIONS; IN-VITRO SUSCEPTIBILITY; AMPHOTERICIN-B; ANTIFUNGAL SUSCEPTIBILITY; BROTH MICRODILUTION; SURVEILLANCE PROGRAM; INVASIVE CANDIDIASIS; TRAILING GROWTH; NORTH-AMERICA; FLUCONAZOLE",

author = "Yun-Liang Yang and Hui-Ting Chen and Lin, {Chao Chih} and Wen-Li Chu and Hsiu-Jung Lo",

year = "2013",

month = jun,

doi = "10.1016/j.diagmicrobio.2013.03.003",

language = "English",

volume = "76",

pages = "182--186",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Science",

number = "2",

}

TY - JOUR

T1 - Species distribution and drug susceptibilities of Candida isolates in TSARY 2010

AU - Yang, Yun-Liang

AU - Chen, Hui-Ting

AU - Lin, Chao Chih

AU - Chu, Wen-Li

AU - Lo, Hsiu-Jung

PY - 2013/6

Y1 - 2013/6

N2 - Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.

AB - Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.

KW - Antifungal; Candida species; Drug susceptibility

KW - BLOOD-STREAM INFECTIONS; IN-VITRO SUSCEPTIBILITY; AMPHOTERICIN-B; ANTIFUNGAL SUSCEPTIBILITY; BROTH MICRODILUTION; SURVEILLANCE PROGRAM; INVASIVE CANDIDIASIS; TRAILING GROWTH; NORTH-AMERICA; FLUCONAZOLE

U2 - 10.1016/j.diagmicrobio.2013.03.003

DO - 10.1016/j.diagmicrobio.2013.03.003

M3 - Article

C2 - 23574935

VL - 76

SP - 182

EP - 186

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

SN - 0732-8893

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ER -