Species distribution and drug susceptibilities of Candida isolates in TSARY 2010

Yun-Liang Yang; Hui-Ting Chen; Chao Chih Lin; Wen-Li Chu; Hsiu-Jung Lo

doi:10.1016/j.diagmicrobio.2013.03.003

Species distribution and drug susceptibilities of Candida isolates in TSARY 2010

Yun-Liang Yang, Hui-Ting Chen, Chao Chih Lin, Wen-Li Chu, Hsiu-Jung Lo

Department of Biological Science and Technology

Research output: Contribution to journal › Article

13 Scopus citations

Abstract

Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	182-186
Number of pages	5
Journal	Diagnostic Microbiology and Infectious Disease
Volume	76
Issue number	2
DOIs	https://doi.org/10.1016/j.diagmicrobio.2013.03.003
State	Published - Jun 2013

Keywords

Antifungal; Candida species; Drug susceptibility
BLOOD-STREAM INFECTIONS; IN-VITRO SUSCEPTIBILITY; AMPHOTERICIN-B; ANTIFUNGAL SUSCEPTIBILITY; BROTH MICRODILUTION; SURVEILLANCE PROGRAM; INVASIVE CANDIDIASIS; TRAILING GROWTH; NORTH-AMERICA; FLUCONAZOLE

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Yang, Y-L., Chen, H-T., Lin, C. C., Chu, W-L., & Lo, H-J. (2013). Species distribution and drug susceptibilities of Candida isolates in TSARY 2010. Diagnostic Microbiology and Infectious Disease, 76(2), 182-186. https://doi.org/10.1016/j.diagmicrobio.2013.03.003

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title = "Species distribution and drug susceptibilities of Candida isolates in TSARY 2010",

abstract = "Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.",

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author = "Yun-Liang Yang and Hui-Ting Chen and Lin, {Chao Chih} and Wen-Li Chu and Hsiu-Jung Lo",

year = "2013",

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doi = "10.1016/j.diagmicrobio.2013.03.003",

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AU - Yang, Yun-Liang

AU - Chen, Hui-Ting

AU - Lin, Chao Chih

AU - Chu, Wen-Li

AU - Lo, Hsiu-Jung

PY - 2013/6

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N2 - Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.

AB - Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.

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DO - 10.1016/j.diagmicrobio.2013.03.003

M3 - Article

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JO - Diagnostic Microbiology and Infectious Disease

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