Soluble polymer-supported synthesis of N, N-di(Boc)-protected guanidines

Jing Ying Shey, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


A novel method for soluble, inexpensive polymer-supported synthesis of internal guanidines with piperazine and piperidine scaffolds has been developed. We carried out a preliminary study on the reactivity of N,N-bis-Boc-1-guanylpyrazole 1, N,N-bis-Boc-thiourea 2 and N,N-di-(tert-butoxycarbonyl)-S-methylisothiourea 3 with resin bound diamines in liquid phase. Guanidines are liberated from the polymer support in high yields and good purity by simple precipitation and washing. This liquid-phase method proves to be a useful tool for constructing guanidine libraries containing a diamine moiety.

Original languageEnglish
Pages (from-to)1423-1425
Number of pages3
Issue number12
StatePublished - 1 Jan 1998

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