Soluble polymer-supported synthesis of arylpiperazines

Pi Chi Pan, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

A method for soluble, inexpensive polymer-supported synthesis of piperazine and piperidine libraries on the basis of nucleophilic aryl substitution (S(N)Ar) and N-acylation is reported. Asymmetric N, N'- disubstituted piperazine and piperidine derivatives, that are potential drug candidates, can be synthesized in quantitative yields and excellent purity after several steps by simple precipitation and washing. This liquid phase method should prove to be a useful tool for constructing combinatorial libraries coataining diamine moiety.

Original languageEnglish
Pages (from-to)9505-9508
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number51
DOIs
StatePublished - 17 Dec 1998

Keywords

  • Acylation
  • Alkylation
  • Piperazine
  • Solid-phase synthesis

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