Soluble polymer-supported synthesis of arylpiperazines

Pi Chi Pan, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Scopus citations


A method for soluble, inexpensive polymer-supported synthesis of piperazine and piperidine libraries on the basis of nucleophilic aryl substitution (S(N)Ar) and N-acylation is reported. Asymmetric N, N'- disubstituted piperazine and piperidine derivatives, that are potential drug candidates, can be synthesized in quantitative yields and excellent purity after several steps by simple precipitation and washing. This liquid phase method should prove to be a useful tool for constructing combinatorial libraries coataining diamine moiety.

Original languageEnglish
Pages (from-to)9505-9508
Number of pages4
JournalTetrahedron Letters
Issue number51
StatePublished - 17 Dec 1998


  • Acylation
  • Alkylation
  • Piperazine
  • Solid-phase synthesis

Fingerprint Dive into the research topics of 'Soluble polymer-supported synthesis of arylpiperazines'. Together they form a unique fingerprint.

  • Cite this