Soluble polymer-supported synthesis of a benzimidazole library

Yu Chung Chi, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The synthesis of benzimidazole 1 using a liquid phase approach is described. Aromatic substitution of immobilized o-fluoronitrobenzene 2 with various amines to o-nitroaniline derivatives 3 is carried out in methylene chloride. Reduction of the aromatic nitro group, followed by subsequent cyclization/elimination gives the benzimidazole skeleton. The crude library members obtained are of high yields and chemical purities after cleavage.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalSynlett
Issue number5
DOIs
StatePublished - May 2000

Keywords

  • Benzimidazole
  • Combinatorial chemistry
  • Liquid-phase method
  • Scaffold
  • Solid-phase method

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