Soluble polymer-supported synthesis of 2-(arylamino)benzimidazoles

Cheng Yi Wu, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A novel liquid-phase method for the construction of biologically important benzimidazoles has been developed. A library of N-substituted 2-aminobenzimidazoles was readily assembled utilizing SNAr reactions, reduction of the nitro group and a one-pot cyclization with isothiocyanate as the key step in the synthesis. The crude benzimidazoles were obtained in 80-99% yields with 78-95% HPLC purity.

Original languageEnglish
Pages (from-to)1529-1533
Number of pages5
JournalTetrahedron Letters
Issue number8
StatePublished - 18 Feb 2002

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