Soft probe scanning electrochemical microscopy with spider array for visualizing biomarkers and redox active proteins in animal tissues

Tzu-En Lin, Yu Jen Lu, Chia Liang Sun, Jyh Ping Chen, Andreas Lesch, Hubert H. Girault

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present soft spider array for gentle contact mode scanning electrochemical microscopy (SECM) imaging of tissues. The spider array contains up to eight completely individual, parallel, and flexible carbon microelectrodes designed to scan square centimeter sized areas on reasonable time scales while avoiding sample aging and electrode fouling. The contact mode enables the scanning of largely curved samples at a constant distance. The spider array is applied for the SECM imaging of the distribution of certain biomarkers, such as tyrosinase, in thin tumor tissues as well as thick tumor blocks. Furthermore, the spider array can be applied for mapping the antioxidant distribution in an apple peel.

Original languageEnglish
Title of host publicationSolid-State Electronics and Photonics in Biology and Medicine 4
EditorsC.-T. Lin, Y.-L. Wang, A. Hoff, M. J. Deen, Z.-H. Lin, L. F. Marsal, W. Wu, Z. Aguilar
PublisherElectrochemical Society Inc.
Pages85-90
Number of pages6
Edition7
ISBN (Electronic)9781607685395
DOIs
StatePublished - 1 Jan 2017
EventSymposium on Solid-State Electronics and Photonics in Biology and Medicine 4 - 231st ECS Meeting 2017 - New Orleans, United States
Duration: 28 May 20171 Jun 2017

Publication series

NameECS Transactions
Number7
Volume77
ISSN (Print)1938-5862
ISSN (Electronic)1938-6737

Conference

ConferenceSymposium on Solid-State Electronics and Photonics in Biology and Medicine 4 - 231st ECS Meeting 2017
CountryUnited States
CityNew Orleans
Period28/05/171/06/17

Fingerprint Dive into the research topics of 'Soft probe scanning electrochemical microscopy with spider array for visualizing biomarkers and redox active proteins in animal tissues'. Together they form a unique fingerprint.

Cite this