Skeletally Diverse Synthesis of Indole-Fused Diazocine and Diazepine Frameworks by One-Pot, Two-Component Cascade Reaction

Tushar Ulhas Thikekar, Manikandan Selvaraju, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

An expeditious and novel strategy has been explored for the synthesis of structurally diverse indole-fused diazocine and diazepine derivatives. A substrate-based diversification approach of methyl-3-aminoindole/indoline benzoates coupled with the Pictet-Spengler reaction and three different reaction cascades furnished indolodiazepine and indoloquinoxalines. The formation of indolodiazocines proceeds through an initial condensation followed by intramolecular alkylation.

Original languageEnglish
Pages (from-to)316-319
Number of pages4
JournalOrganic Letters
Volume18
Issue number2
DOIs
StatePublished - 15 Jan 2016

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