Simultaneous identifications of the minimum effective dose in each of several groups

Show Li Jan*, Yuh Ing Chen, Gwowen Shieh

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

One primary goal in dose-response studies for drug development is to identify the minimum effective dose (MED) which is the lowest dose level with an effect that exceeds that of the zero dose control. In this paper, we consider step-down closed testing procedures on the basis of pairwise and Helmert contrasts suggested by Tamhane et al. [Tamhane, A.C., Hochberg, Y., and Dunnett, C.W., 1996, Multiple test procedures for dose finding. Biometrics, 52, 21-37.] for the situation where one wishes to make all such MED identifications simultaneously in each of several groups. An example is given to illustrate the proposed tests. The Monte Carlo studies are further implemented to compare the relative error rate and power performances of the proposed tests.

Original languageEnglish
Pages (from-to)149-161
Number of pages13
JournalJournal of Statistical Computation and Simulation
Volume77
Issue number2
DOIs
StatePublished - 1 Feb 2007

Keywords

  • Dose-response study
  • Helmert contrasts
  • Pairwise contrasts
  • Simultaneous inference
  • Step-down closed test

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