Simulation of axon activation by electrical stimulation applying alternating-direction-implicit finite-difference time-domain method

T.m. Choi*, Shu Hai Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In a typical approach to model electrical stimulation of an axon, a cable model equivalent to an axon was placed in a simple homogeneous medium. An electrode was used to induce an excitation to stimulate the cable model, and then the transmembrane potentials and the ionic currents in the cable model in temporal domain were observed. Unfortunately, this simulation approach is not realistic since inhomogeneous tissues near the axon is not considered. In this paper, the alternating-direction-implicit finite-difference time-domain (ADI-FDTD) method is coupled with the equivalent model of a membrane (the Hodgkin-Huxley model), and a novel simulation scheme is developed to predict axon activation. By testing axon activation with current excitation, the simulation results show the new method is useful for simulating axon activation.

Original languageEnglish
Article number6136610
Pages (from-to)639-642
Number of pages4
JournalIEEE Transactions on Magnetics
Volume48
Issue number2
DOIs
StatePublished - 1 Feb 2012

Keywords

  • Alternating-direction-implicit finite-difference time-domain (ADI-FDTD)
  • axon stimulation
  • cable model
  • Hodgkin-Huxley (HH) model

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