Simple and efficient one pot synthetic protocol to construct morpholin-2-ones

Gorakh S. Yellol, Debendra K. Mohapatra, Mukund K. Gurjar, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A new one pot synthetic method to construct 3-substituted morpholine-2-one derivatives is presented. Amino acids refluxed with 1,2-dibromoethane and potassium carbonate in acetonitrile followed by treatment with benzyl bromide in same pot furnished the 3-substituted N-benzyl-morpholine-2-ones in good yields. The simplicity of the reaction conditions and versatility of resulted scaffold to generate wide variety of molecules makes this method more attractive for synthetic organic chemists.

Original languageEnglish
Pages (from-to)431-439
Number of pages9
JournalHeterocycles
Volume82
Issue number1
DOIs
StatePublished - 1 Dec 2010

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