Self-assembly behavior and doxorubicin-loading capacity of acylated carboxymethyl chitosans

Kun Ho Liu, Bo Rong Chen, San-Yuan Chen, Dean-Mo LIu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


A new type of acylated carboxymethyl amphiphilic chitosan (ACC) with the use of acyl chain of varying lengths, from C2 to C12, and various degrees of acyl substitution was successfully synthesized and has been characterized in terms of its self-assembly behavior, structural stability, and drug encapsulation. The resulting nanostructure of the ACC nanoaggregates can be well manipulated through a control of hydrophobicity. Structural evolution of the self-assembled nanoaggregates is extensively characterized via 1H NMR, FTIR, DSC, and TEM. A critical value of the hydrophobic effect, (X DH × XCn), i.e., a product of "degree of acyl substitution" and "carbon number of acyl chain", can be employed as an indicator for structural variation of the nanoaggregates: when (X DE × XCn) exceeded 1.5, the architecture of the nanoaggregates underwent a structural transformation from solid nanoparticle to hollow nanocapsules. The nanoaggregates exhibited an excellent colloidal and structural stability in aqueous medium. An improved affinity toward drug encapsulation, i.e., doxorubicin, can be technically designed according to the amphiphilic nature of the resulting nanoaggregates for drug delivery.

Original languageEnglish
Pages (from-to)11800-11807
Number of pages8
JournalJournal of Physical Chemistry B
Issue number35
StatePublished - 3 Sep 2009

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