Secoiridoid Glucosides and Anti-Inflammatory Constituents from the Stem Bark of Fraxinus chinensis

Hao-Chiun Chang, Shih-Wei Wang, Chin-Yen Chen, Tsong-Long Hwang, Ming-Jen Cheng, Ping-Jyun Sung, Kuang-Wen Liao, Jih-Jung Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Qin Pi (Fraxinus chinensis Roxb.) is commercially used in healthcare products for the improvement of intestinal function and gouty arthritis in many countries. Three new secoiridoid glucosides, (8E)-4 ''-O-methylligstroside (1), (8E)-4 ''-O-methyldemethylligstroside (2), and 3 '',4 ''-di-O-methyl-demethyloleuropein (3), have been isolated from the stem bark of Fraxinus chinensis, together with 23 known compounds (4-26). The structures of the new compounds were established by spectroscopic analyses (1D, 2D NMR, IR, UV, and HRESIMS). Among the isolated compounds, (8E)-4 ''-O-methylligstroside (1), (8E)-4 ''-O-methyldemethylligstroside (2), 3 '',4 ''-di-O-methyldemethyloleuropein (3), oleuropein (6), aesculetin (9), isoscopoletin (11), aesculetin dimethyl ester (12), fraxetin (14), tyrosol (21), 4-hydroxyphenethyl acetate (22), and (+)-pinoresinol (24) exhibited inhibition (IC50

Original languageEnglish
Article number5911
Number of pages19
JournalMolecules
Volume25
Issue number24
DOIs
StatePublished - Dec 2020

Keywords

  • Fraxinus chinensis
  • Oleaceae
  • stem bark
  • secoiridoid
  • anti-inflammatory activity
  • CHEMICAL-CONSTITUENTS
  • SUPEROXIDE
  • FLOWERS
  • FRUITS
  • ROOTS
  • CELLS

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