Abstract
Pharmacologically interesting tetrahydro-β-carbolinehydantoins have been prepared through four-step traceless synthesis by a combinatorial approach. Two-arm PEG 1 (MW ≈ 4000) was used as a soluble polymer support and reacted with Fmoc-protected L-tryptophane 2 to form bis-ester 3. The resulting polymer-supported amino ester 3 was deprotected, and amino ester 4 underwent Pictet-Spengler reaction with varoius ketones to form tricyclic indoles S. The nucleophilic piperidine in the tricyclic indole reacted with isocyanate to generate the urea intermediates and simultaneously intramolecular cyclization to release the target compounds 7 from the support in good yields.
Original language | English |
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Pages (from-to) | 618-626 |
Number of pages | 9 |
Journal | Journal of Combinatorial Chemistry |
Volume | 9 |
Issue number | 4 |
DOIs | |
State | Published - 1 Jul 2007 |