Sample Preparation on Micro-Electrode-Dot-Array Digital Microfluidic Biochips

Zipeng Li, Kelvin Yi Tse Lai, Krishnendu Chakrabarty, Tsung Yi Ho, Chen-Yi Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

Sample preparation in digital microfluidics refers to the generation of droplets with target concentrations for onchip biochemical applications. In recent years, digital microfluidic biochips (DMFBs) have been adopted as a platform for sample preparation. However, there remain one major problem associated with sample preparation on a conventional DMFB. For conventional DMFBs, only a (1:1) mixing/splitting model can be used, leading to an increase in the number of fluidic operations required for sample preparation. To overcome the drawback, we adopt a next generation DMFB platform, referred to as micro-electrode-dot-array (MEDA), for sample preparation. We propose the first sample preparation method that exploits the MEDA-specific advantages of fine-grained control of droplet sizes and real-time droplet sensing. Experimental demonstration using a fabricated MEDA biochip and simulation results highlight the effectiveness of the proposed sample-preparation method.

Original languageEnglish
Title of host publicationProceedings - 2017 IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2017
EditorsRicardo Reis, Mircea Stan, Michael Huebner, Nikolaos Voros
PublisherIEEE Computer Society
Pages146-151
Number of pages6
ISBN (Electronic)9781509067626
DOIs
StatePublished - 20 Jul 2017
Event2017 IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2017 - Bochum, North Rhine-Westfalia, Germany
Duration: 3 Jul 20175 Jul 2017

Publication series

NameProceedings of IEEE Computer Society Annual Symposium on VLSI, ISVLSI
Volume2017-July
ISSN (Print)2159-3469
ISSN (Electronic)2159-3477

Conference

Conference2017 IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2017
CountryGermany
CityBochum, North Rhine-Westfalia
Period3/07/175/07/17

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  • Cite this

    Li, Z., Lai, K. Y. T., Chakrabarty, K., Ho, T. Y., & Lee, C-Y. (2017). Sample Preparation on Micro-Electrode-Dot-Array Digital Microfluidic Biochips. In R. Reis, M. Stan, M. Huebner, & N. Voros (Eds.), Proceedings - 2017 IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2017 (pp. 146-151). [7987510] (Proceedings of IEEE Computer Society Annual Symposium on VLSI, ISVLSI; Vol. 2017-July). IEEE Computer Society. https://doi.org/10.1109/ISVLSI.2017.34